Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

The overall research objective of my group is to combine novel cell scaffold development with mechanical cues ... chemistries that exhibit a range of macroscopic properties and degradation profiles.

This new approach allows studying cellular degradation of proteins carrying a defined ubiquitin code. The researchers tag a fluorescent protein with a known ubiquitin code. Then, they deliver the ...

This course covers the requirements for construction and the safe construction and use of scaffolding using the OSHA construction scaffold standard as a guide. Course topics include hazards associated ...