Scientists had previously identified the functions of two distinct pathways and types of dopamine receptors in the forebrain: the D1 receptors, which activate neurons, and the D2 receptors ...
Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...