The company has discontinued the Phase I/II trial of its only clinical candidate due to a potential “unfavourable ...

Kinase activity has not been detected for several CDK-related proteins, but they are still known as PFTK2, PCTK2 or CCRK, where 'K' stands for 'kinase'. Finally, most 'cyclins' do not cycle.

Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22+ Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia We enrolled 16 patients ...

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to ...

When this protein - cyclin-dependent kinase (CDK) - was suppressed, the treatment also prevented a change in the colour of their fur. This leaves the door open for scientists to help delay the ...

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial ...

The conformational activation of Src kinase must be carefully regulated in cells for proper function and to avoid disease. The active and down-regulated forms of Src are defined by crystallography, ...

We enrolled 16 patients with PMC in a single-arm personalized cancer therapy trial. For all patients, tumor tissue and/or circulating tumor DNA genomic profiling using next-generation sequencing and, ...