Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1 ...

A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration ...

A review of the scientific literature suggests the potential of caspase-4/5 as targets for a broad range of inflammatory diseases, including inflammatory bowel disease, hidradenitis suppurativa ...

For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...

This Progress article describes recent studies showing that the human lipopolysaccharide sensor caspase-4 activates pro-IL-18 and causes vascular leakage by inducing pyroptosis in endothelial cells.