Tonight we have the Buffalo Bills hosting the San Francisco 49ers. Kickoff is scheduled for 8:15 pm EST. The 5-6 San Francisco 49ers come into this game fighting for their playoff lives.

The Bills reached a record low this past season in reported bad behavior at Highmark Stadium, according to data the team ...

The 49ers have reportedly granted Samuel permission to seek a trade, and the Buffalo Bills appear to be a reasonable ...

The San Francisco 49ers were hit hard by injury issues last season, including a couple to star running back Christian ...

Here are 10 topics from the NFL scouting combine that relate to the 49ers, who will be represented Wednesday by general ...

The Washington Commanders solidified themselves among NFC betting favorites for the Super Bowl after their trade for San ...

But if he were to do so in Buffalo, he'd be doing so with one of the game's best offensive lines in front of him, alongside a ...

San Francisco 49ers' rival, the Los Angeles Rams, are going around again with Matthew Stafford, much to the delight of his ...

The San Francisco 49ers and head coach Kyle Shanahan have announced the team's latest coaching hires and title changes ahead ...

As the 49ers prepare for the 2025 NFL Draft, we ran a mock simulator to see who PFF thinks the team will take, and a few may surprise you.

Former Buffalo Bills offseason lineman Jon Feliciano has decided to retire from the NFL. But Feliciano will be keeping his ...