People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

DDR defects not only predispose to cancer ... a process which is defective in hereditary breast cancer caused by inactivation of the BRCA1 or BRCA2 gene. Therefore, PARP inhibition kills these ...

This can be particularly helpful for people with a family history of breast and ovarian cancer and BRCA gene mutations. Everyone is born with the BRCA 1 and BRCA2 genes. You inherit two sets of ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...

On April 1, 2024, I walked into an operating room . I elected to have a preventative double mastectomy, removing my breasts in hopes of eliminating the possibility of a breast cancer diagnosis in the ...

“The BRCA1 and BRCA2 genes, when mutated, are particularly associated with breast and ovarian cancers. Other genes, including ATM, CHEK2, CDH1, PTEN, TP53, and NF1, also contribute to higher ...

Mutations in the BRCA1 and BRCA2 genes, which are more commonly associated with female breast and ovarian cancer, can increase a man’s risk for breast cancer. About 0.2% to 1.2% of men with an ...

In recent years, her focus has shifted to oncology, where she has become a trusted voice in understanding genetic risks for cancer, notably the BRCA gene mutation. One of the key elements in ...

Testing for BRCA mutations linked to breast and ovarian cancers could become easier and more accessible with the help of artificial intelligence, potentially allowing earlier treatment.

A new study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is shedding light on a novel role of breast cancer gene 1 (BRCA1) in tumor suppression.