People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of ...

People inherit two copies of each gene -; one from each parent -; an evolutionary fail-safe to ensure survival even when one of them doesn't function.

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

Indeed, mutations in BRCA1 are known to predispose individuals ... the effects of the PARP1 inhibitor AZD2281 in a mouse model of breast cancer. Treatment of tumour-bearing mice with AZD2281 ...

University of Oregon biologists have uncovered a mechanism by which a well-known breast cancer gene also influences fertility. Mutations in the BRCA1 gene sharply increase a person's risk of ...

However, a negative result might mean that you didn’t inherit a mutated BRCA1 or BRCA2 gene but you still may be at risk of cancer due to other biological or environmental factors. In these ...

Female carriers of germline BRCA1 mutations have a lifetime risk of breast cancer exceeding 80% and of ovarian cancer approaching 60%. The cumulative lifetime risk of developing either breast or ...

Everything inside the mouse – its nerves, tissues and organs – are made invisible by a chemical process A new scanning method involving a see-through mouse could improve how cancer drugs are ...

UAB researchers have reversed metabolic dysfunction-associated steatohepatitis (MASH) in mouse models. MASH is a severe liver disease associated with obesity and type 2 diabetes that affects more than ...

The work points toward a promising new immunotherapy approach for ovarian cancer, which ... The researchers successfully deployed CAR-T in a mouse model of ovarian ... July 21, 2023 ...

B) Improved survival in a mouse model of E-cadherin (Cdh1 ... Targeting E-cadherin defects in lobular breast cancer Building on our identification of synthetic lethality between BRCA1/BRCA2 mutations ...

A new study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is shedding light on a novel role of breast cancer gene 1 (BRCA1) in tumor suppression.