The immune system produces a huge variety – hundreds of billions – of high-affinity antibodies. Immunologists have been asking how B cells accomplish this for decades, and in the past five years, the ...

Polyreactive IgM natural antibodies are produced by mainly B-1 cells which account for most ... in the human are at the basis of our proposed structure-function model in which the antigen binding ...

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal ...

Antibodies, also known as immunoglobulins (IGs), are glycoproteins produced in response to an immune reaction and exhibit high specificity for the antigens that elicit the response. An antibody ...

Ablexis and AlivaMab Discovery Services together launch antibody drug discovery ... High-throughput screening of the diversity of both plasma and memory IgG + B cell repertoires, interrogating ...

[37] In addition, the loss of B-cell diversity and affinity as a result of disrupted germinal center formation in aging impairs the generation of high-affinity antibodies against antigen ...

When fighting against pathogens, the adaptive immune system generates T cells and antibody-producing B cells that can provide ... which maximizes epitope diversity and overcomes restriction ...