Lot-et-Garonne is a department in the Nouvelle-Aquitaine region of Southwestern France. Named after the rivers Lot and Garonne, it ha…Lot-et-Garonne is a department in the Nouvelle-Aquitaine region of Southwestern France. Named after the rivers Lot and Garonne, it had a population of 331,271 in 2019. Its prefecture and largest city is Agen.