Laurel is a city in Maryland, United States, located midway between Washington, D.C. and Baltimore on the banks of the Patuxent River, …Laurel is a city in Maryland, United States, located midway between Washington, D.C. and Baltimore on the banks of the Patuxent River, in northern Prince George's County. Founded as a mill town in the early 19th century, Laurel expanded local industry and was later able to become an early commuter town for Washington and Baltimore workers following the arrival of the Baltimore and Ohio Railroad in 1835. Largely residential today, the city maintains a historic district centered on its Main Street, highlighting its industrial past.