Tours is the largest city in the region of Centre-Val de Loire, France. It is the prefecture of the department of Indre-et-Loire. The commune of T…Tours is the largest city in the region of Centre-Val de Loire, France. It is the prefecture of the department of Indre-et-Loire. The commune of Tours had 136,463 inhabitants as of 2018 while the population of the whole metropolitan area was 516,973.