Rhône is a French department located in the east-central administrative region of Auvergne-Rhône-Alpes. Named after the river Rhône, its pr…Rhône is a French department located in the east-central administrative region of Auvergne-Rhône-Alpes. Named after the river Rhône, its prefecture is Lyon. Its sole subprefecture is Villefranche-sur-Saône. Including the Lyon Metropolis, it had a population of 1,875,747 in 2019.