Port St. Joe is a city and the county seat of Gulf County, Florida. It is located at the intersection of U.S. Highway 98 and State Road 71. As of the 2020 census, the population was 3,357. St. Joseph was founded in 1835 by businessmen from nearby Apalachicola, which was troubled by legal conflict over land titles. It was mostly abandoned in 1841, after a yellow fever epidemic; a storm surge produced by a hurricane in 1844 destroyed what structures remained.
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