Picos is a municipality in the state of Piauí in the Northeast region of Brazil. Picos is the state's third-largest city, located in the south-centr…Picos is a municipality in the state of Piauí in the Northeast region of Brazil. Picos is the state's third-largest city, located in the south-central region of Piauí and is the most economically developed city in the region. The city's financial prosperity, combined with its geographical location, gives Picos a "commercial hub" status, especially for fuel and honey. As of 2020, the population was approximately 78,431.