Orgon is a commune in the Bouches-du-Rhône department in the Provence-Alpes-Côte d'Azur region in Southern France. It is located …Orgon is a commune in the Bouches-du-Rhône department in the Provence-Alpes-Côte d'Azur region in Southern France. It is located on the departmental border with Vaucluse, which follows the river Durance.