Rhône is a department of east-central France, in the central-southeastern Auvergne-Rhône-Alpes region. Named after the river Rhône, its pref…Rhône is a department of east-central France, in the central-southeastern Auvergne-Rhône-Alpes region. Named after the river Rhône, its prefecture is Lyon. Its sole subprefecture is Villefranche-sur-Saône. In 2019, it had a population of 1,875,747.