Orange is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in Southeastern France. It is about 21 km north o…Orange is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in Southeastern France. It is about 21 km north of Avignon, on the departmental border with Gard, which follows the Rhône and also constitutes the regional border with Occitania. Orange is the second-most populated city in Vaucluse, after Avignon.