Mesquite is a city in Clark County, Nevada, United States adjacent to the Arizona state line and 80 miles northeast of Las Vegas on Interstate …Mesquite is a city in Clark County, Nevada, United States adjacent to the Arizona state line and 80 miles northeast of Las Vegas on Interstate 15. As of the 2020 census, the city had a population of 20,471. The city is located in the Virgin River valley adjacent to the Virgin Mountains in the northeastern part of the Mojave Desert. It is home to a growing retirement community, as well as several casino resorts and golf courses.
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