Lonoke is the second most populous city in Lonoke County, Arkansas, United States, and serves as its county seat. According to 2010 Unite…Lonoke is the second most populous city in Lonoke County, Arkansas, United States, and serves as its county seat. According to 2010 United States Census, the population of the city is 4,245. It is part of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area.