Cuero is a city in and the county seat of DeWitt County, Texas, United States. Its population was 8,128 at the 2020 census. The city of Cuer…Cuero is a city in and the county seat of DeWitt County, Texas, United States. Its population was 8,128 at the 2020 census. The city of Cuero got its start in the mid-19th century as a stopping point on the Chisholm Trail cattle route to Kansas. According to the Handbook of Texas Online, "Gustav Schleicher founded the latter town as a way-station and moved to it soon afterward, in 1872." It was not recognized as a town until 1873, though, when it was officially founded. The city was named for the Spanish word "hide", referring to the leather made from animal hides. The industry was extremely short-lived, however, and gave way to various forms of ranching. The city had several Old West gunfights related to clan feuding following the Civil War.
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