Cayo Santiago, also known as Santiago Island, Isla de los monos, is located at 18°09′23″N 65°44′03″W / 18.15639°N 65.73417°W, 0.59 mi 0.6 mi to the east of Punta Santiago, Humacao, Puerto Rico. The island measures approximately 37.5 acres, or 660 yards, north–south and 440 yards east–west, including a "Small Key" which is connected to the m…Cayo Santiago, also known as Santiago Island, Isla de los monos, is located at 18°09′23″N 65°44′03″W / 18.15639°N 65.73417°W, 0.59 mi 0.6 mi to the east of Punta Santiago, Humacao, Puerto Rico. The island measures approximately 37.5 acres, or 660 yards, north–south and 440 yards east–west, including a "Small Key" which is connected to the main area by a narrow, sandy isthmus. Six-hundred meters west of the southernmost point is a shoal, Bajo Evelyn, which has a shallow depth of 8 fathoms. While the island is flat to the north, it reaches a height of 114.5 ft, 1.8 mi southwest of the island's port, on a small, rocky hill called El Morrillo, rising abruptly from the water and the surrounding lowlands. The area of the island is 0.054 sq mi: Block 2000, Census Block Group 2, Census tract 1801, Humacao Municipio, Puerto Rico), of which the northeastern peninsula accounts for about 0.01 sq mi.