Brno is a city in the South Moravian Region of the Czech Republic. Located at the confluence of the Svitava and Svratka rivers, Brno ha…Brno is a city in the South Moravian Region of the Czech Republic. Located at the confluence of the Svitava and Svratka rivers, Brno has about 400,000 inhabitants, making it the second-largest city in the Czech Republic after the capital, Prague, and one of the 100 largest cities of the European Union. The Brno metropolitan area has approximately 730,000 inhabitants.