Arpino is a comune in the province of Frosinone, in the Latin Valley, region of Lazio in central Italy, about 100 km SE of Rome. Its Roman name …Arpino is a comune in the province of Frosinone, in the Latin Valley, region of Lazio in central Italy, about 100 km SE of Rome. Its Roman name was Arpinum. The town produced two consuls of the Roman republic: Gaius Marius and Marcus Tullius Cicero.